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Histologic findings in cases with fatal retinoic acid syndrome

Histologic findings in cases with fatal retinoic acid syndrome
#00015197
Author: Tsila Zuckerman, Chezi Ganzel, Martin S. Tallman, and Jacob M. Rowe
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 12/09/2012

Histologic appearance of normal lung tissue. L indicates lung alveolae in normal lung. *Normal neutrophil in microvasculature. (B) Lung tissue showing infiltration of alveolae with leukocytes from a patient who died of retinoic acid syndrome. w indicates myeloid cells in the airspace (most leukocytes to left of “w”); the lobated nuclei of myeloid cells is prominently seen. Arrows indicate fibrinous exudate resulting from vascular leak of serum fibrin.