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This high power view further highlights the morphology of the malignant cells. Note the nuclear pleomorphism and the characteristic anaplastic cells. Identical cells were observed in the bone marrow. Hodgkin's lymphoma (HL) with Reed-Sternberg cell variants can sometimes resemble ALCL. However, the tumors are unrelated, as the malignant cells in ALCL are T-cells, whereas the vast majority of HL are considered to be of B-cell origin. ALCL is EBV-negative. (H & E 40×)
Anaplastic Large-Cell Lymphoma – Nodal Involvement - 3.
#00003347
Author: John Lazarchick; Gregor Krings;
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 07/01/2007
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 07/01/2007
This high power view further highlights the morphology of the malignant cells. Note the nuclear pleomorphism and the characteristic anaplastic cells. Identical cells were observed in the bone marrow. Hodgkin's lymphoma (HL) with Reed-Sternberg cell variants can sometimes resemble ALCL. However, the tumors are unrelated, as the malignant cells in ALCL are T-cells, whereas the vast majority of HL are considered to be of B-cell origin. ALCL is EBV-negative. (H & E 40×)
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