Microgranular variant of APML

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Microgranular variant of APML

#00063036

Author: Ke Xu, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 05/29/2020

An 89-year-old lady presented with general deterioration. Hb 102g/L, WBC 59x10^9/L (neutrophil 6.04x 10^9/L, lymphocyte 0.89x 10^9/L), Platelet 19x 10^9/L. Blood film showed bilobed promyelocytes without Auer rods, in consistent with microgranular variant of acute promyelocytic leukemia. Flow cytometry identified 95% abnormal myeloid precursors. They are CD34-DR-CD117+CD33+cMPO+. Urgent FISH identified PML-RARA in 96% cells analysed. She was too unwell for treatment and was managed with palliation.

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