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Neutrophil clumping at edge of peripheral blood smear caused variation in absolute neutrophil count from automated (1.5) to manual (0.6) differential. Manual differential by tech did not include clumped cells and thus resulted in false low ANC. Rare case reports secondary to IgM or temperature related clumping.
Neutrophil clumping in peripheral blood
#00011293
Author: Wendy Moreland, MD
Category: Laboratory Hematology > Basics of automated cell counts > Causes of inaccurate white blood cell counts > Falsely low neutrophil count > Neutrophil aggregation
Published Date: 05/03/2012
Category: Laboratory Hematology > Basics of automated cell counts > Causes of inaccurate white blood cell counts > Falsely low neutrophil count > Neutrophil aggregation
Published Date: 05/03/2012
Neutrophil clumping at edge of peripheral blood smear caused variation in absolute neutrophil count from automated (1.5) to manual (0.6) differential. Manual differential by tech did not include clumped cells and thus resulted in false low ANC. Rare case reports secondary to IgM or temperature related clumping.
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