Pseudo Pelger-Huët Anomaly

#00017390
Author: Carole Bitar and Nakhle Saba
Category: Laboratory Hematology > Basic cell morphology > Morphologic variants of white blood cells > Hyposegmented neutrophil  
Published Date: 03/22/2013

Wright stain showing a Pseudo-Pelger-Huet neutrophil and a band on the peripheral blood of a patient with a Chronic Myeloproliferative Disorder, Unclassified. Pelger-Huet anomaly is an autosomal dominant benign disorder, while Pseudo-Pelger-Huet anomaly (PHA) is an acquired disease. The presence of PHA cells on a blood film may reflect an underlying myeloproliferative disease (classically CML) or myelofibrosis, and should trigger prompt investigations.