Author: Marshall Kadin
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Leukemias > Sezary Syndrome
Published Date: 12/10/2004
Blood smear stained with Giemsa showing Sézary cell with convoluted nucleus. Sézary cells may be confused with monocytes which are of similar size and have a folded nucleus. Further distinction is facilitated by Periodic-acid-Schiff (PAS) stain which shows coarse granules surrounding the nucleus in cytoplasm of Sézary cells and fine dispersed granules in monocytes. Flow cytometry will also identify Sézary cells as T cells which express surface CD3 and CD4, but commonly lack CD7 antigen.