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The malignant cells stain positive for the T-cell membrane protein CD43, as is evident in two thirds of cases. ALCL cells may also be positive for additional T-cell cytoplasmic membrane markers, such as CD3, CD4, CD5, or CD8. The malignant cells in this case stained positive for CD5 (not shown). In addition, they tend to stain with markers such as perforin, TIA-1, and granzyme B, which reflect the cytotoxic T-cell origin of the tumor.
Anaplastic Large Cell Lymphoma Involving the Bone Marrow - 9.
#00003320
Author: John Lazarchick; Gregor Krings;
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 10/31/2011
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 10/31/2011
The malignant cells stain positive for the T-cell membrane protein CD43, as is evident in two thirds of cases. ALCL cells may also be positive for additional T-cell cytoplasmic membrane markers, such as CD3, CD4, CD5, or CD8. The malignant cells in this case stained positive for CD5 (not shown). In addition, they tend to stain with markers such as perforin, TIA-1, and granzyme B, which reflect the cytotoxic T-cell origin of the tumor.
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