Chédiak-Higashi syndrome (CHS)

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Chédiak-Higashi syndrome (CHS)

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Author: Akbar Dorgalaleh (Ph.D), Jamal Rashid Panah (BS.c)
Category: Myeloid Disorders > Neutrophil function disorders
Published Date: 05/27/2016

Chédiak-Higashi syndrome (CHS) in a patient with abnormal granules in leukocytes. Chédiak–Higashi syndrome is an autosomal recessive disorder that occurs in patients with a mutation of a lysosomal trafficking regulator protein (CHS1) leading to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent infections, partial albinism and peripheral neuropathy.

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