Myeloid sarcoma, NPM1 mutation

Myeloid sarcoma, NPM1 mutation
Author: Mir Alikhan, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Myeloid sarcoma
Published Date: 09/10/2021

Figure 4: Next-generation sequencing analysis on the FFPE tissue demonstrated a pathogenic NPM1 mutation (p.W288*): a four base-pair insertion leading to frameshift and alteration of the C-terminus of the Npm1 protein (where nuclear export signals reside), causing abnormal localization to the cytoplasm. The image is visualization of the NGS analysis using Integrated Genomics Viewer (IGV) software.