A 68-year-old male presented with chest and back pain for one month, progressive lower extremity weakness 3 days. A magnetic resonance imaging (MRI) study of the thoracic vertebrae showed T6 vertebral and accessories abnormal signals. Doubt tuberculosis is the major pathogenic reason and diagnosis of tumor need to be exclusion, which cause T6 vertebral compression fracture. patient admission to hospital for surgery. Bone marrow aspirate by Wright’s stain showed diffuse and monotonous infiltrate of large cells with either plasmablastic or immunoblastic morphology. Nuclei are large, oval to round with open chromatin and prominent nucleoli. The postoperation histopathologic findings was small neoplastic population infiltration. Immunohistochemical staining of the neoplastic cells were positive for VS38C(+), EMA(+), LCA(+), CD68(+), CD3(partly + ), CD56(few + ), CD117(+) and negative for PSA, TTF-1, CK, HMB-45, A103, CD138, CD19, CD20, CD79a, CD15, S100, ALK. The case demonstrated an immu