Chediak-Higashi Syndrome

Chediak-Higashi Syndrome
Author: Perla Vicari, MD, PhD
Category: Laboratory Hematology > Basic cell morphology > Morphologic variants of white blood cells > Chediak-Higashi Syndrome  
Published Date: 12/13/2021

Bone marrow smear from a patient with Chediak-Higashi syndrome shows giant granules in the cytoplasm of myeloid precursors (arrows). These granules are formed by the inappropriate fusion of lysosomes and endosomes (May-Grünwald-Giemsa stain).