Hemophagocytosis and increased bone marrow iron stores

Hemophagocytosis and increased bone marrow iron stores
Author: Martin Pacheco, MD; Eleazar Hernandez Ruiz, MD; Lourdes Elena Galaz Cordero, MD
Category: Reactive Marrow > Reactive changes > Histiocytes > Hemophagocytosis
Published Date: 06/18/2022

59 yr-old man with AML and FLT3 ITD mutation was treated with standard 7+3 chemotherapy and 14 day course of midostaurin. He developed fusariosis during the period of severe neutropenia, for which he recieved liposomal amphotericin B and voriconazol. Bone marrow aspiration after recovery revealed <5% blasts, increased number of macrophages with abundant dark greenish-brown inclusions, as well as hemophagocytosis. Perls Prussian blue stain revealed increased iron stores. Blood and bone marrow cultures after treatment showed no growing of Fusarium spp.