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Figure showing Mott cells with classical bunch of grapes appearance in Bone Marrow Aspirate Smears.

The term "Mott cell" is attributed to Frederick Walker Mott, a surgeon who first identified these cells in the brains of monkeys affected with trypanosomiasis in 1901. He originally termed them "morular cells" due to their resemblance to mulberries, recognizing them as plasma cells indicative of chronic inflammation. However, William Russell is likely the first to describe this appearance in 1890, although he did not fully grasp the nature of the cell or the significance of its inclusions.

                   A Mott cell is a term used to describe a plasma cell that contains numerous intracytoplasmic inclusions known as Russell bodies. These inclusions are eosinophilic structures composed mainly of immunoglobulins that have been synthesized by the plasma cell. Mott cells have the classic “bunch of grapes” appearance of the plasma cell cytoplasm packed with Ig inclusions (Russell bodies). It can be seen in multiple myeloma, various plasma cell disorders, and reactive plasmacytosis associated with chronic inflammatory conditions, autoimmune diseases, and uncommon disorders such as Wiskott-Aldrich syndrome and von Recklinghausen's neurofibromatosis.