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T cell ALL

Author:  Katherine Calvo, MD, PhD, 09/29/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > T-lymphoblastic leukemia/lymphoma
Published Date: 02/25/2016
     
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6 year old female with anemia and thrombocytopenia 

Peripheral Blood

6 year old female with anemia and thrombocytopenia with blasts on peripheral smear

T-cell-ALL-peripheral-blood
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Biopsy

Bone marrow core biopsy low power, hypocellular for age

Bone marrow core biopsy high power, reduced normal elements and increased blasts.

T-cell-ALL-Marrow-Biopsy
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T-cell-ALL-Marrow-Biopsy
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Aspirate

Bone marrow aspirate shows blasts

T-cell-ALL-Biopsy
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T-cell-ALL-Biopsy
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Special Stains

CD 3 positive on special stains

T-cell-ALL-Special-Stains
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Flow Cytometry

Flow cytometric analysis of the marrow aspirate identifies 77% abnormal T-lineage blasts:

CD3+ (cytoplasmic and surface), CD5+, CD7+, HLA-DR+, CD34-, CD8-, CD4-, CD19-, and TdT-.

Diagnosis:  T lymphoblastic leukemia

T-cell-ALL-Flow-Cytometry
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