Myeloid leukemia of Down syndrome core biopsy low power

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Myeloid leukemia of Down syndrome core biopsy low power

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Author: Kristian T. Schafernak
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Myeloid proliferations related to Down syndrome > Myeloid Leukemia associated with Down Syndrome
Published Date: 10/28/2016

Low-power (hematoxylin and eosin) photomicrograph of the bone marrow from a child with Down syndrome, now with myeloid leukemia. Note the tremendous megakaryocytic hyperplasia. Streaming of nuclei is apparent at left, suggesting myelofibrosis, likely due to transforming growth factor beta elaborated by the tumor cells.

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