Monoblasts in peripheral blood

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Monoblasts in peripheral blood

#00061564

Author: Joseph Cho, MD, PhD; Girish Venkataraman, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > AML not otherwise specified > Acute monoblastic/monocytic leukemia
Published Date: 07/03/2018

Wright stain shows two circulating monoblast in the peripheral blood. The monoblasts feature large nuclei with prominent nucleoli, fine chromatin and small indentations and basophilic cytoplasm without granules. The monoblast in the lower right has abundant cytoplasm, vacuoles and pseudopods which may lead to misidentifying it as a monocyte. However its nuclear features (large rounded nuclei with prominent nucleoli and fine chromatin) are characteristic of a monoblast. Circulating monoblasts are observed in monoblastic and myelomonocytic leukemias.

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