B-ALL with asymptomatic CSF relapse

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B-ALL with asymptomatic CSF relapse

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Author: Ke Xu, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Precursor Lymphoid Neoplasms > B-lymphoblastic leukemia/lymphoma > B-Lymphoblastic Leukemia/Lymphoma, with recurrent genetic abnormalities > B-Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34;q11.2); BCR-ABL1
Published Date: 09/08/2020

A man with Ph+ B-ALL was treated to morphological remission with low level of MRD positivity. Unfortunately 80% blasts were found in routine lumbar puncture CSF specimen. Flow cytometry identified CD34-CD19+CD10+CD38+CD22+ B-lymphoblasts. Repeat bone marrow aspirate and trephine showed no morphological or flow cytometric evidence of leukaemia, and MRD remained at low level positivity.

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