Pseudo-Auer rods in a patient with newly diagnosed IgG myeloma
Author: Stefani Parmentier and Joergen Radke Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Plasma Cell Neoplasm > Plasma cell myeloma Published Date: 07/22/2012
An 83-year-old woman with chronic gastrointestinal problems developed retinal vein thrombosis. Laboratory tests revealed an erythrocyte sedimentation rate of 45, renal dysfunction (GFR 25 mL/min), and mild anemia (hemoglobin 10 G/dL) with normal white cells and platelets. ß2-microglobulin was elevated at 8.06 mg/L. A plasma cell dyscrasia was suspected and immunoglobulin testing showed monoclonal IgG, ? in the serum (28.9 g/L) with free ? chains (1.2 g/L), and ? light chains in the urine (10.2 g/L). Bone marrow aspirate contained ~ 10% plasma cells (CD38+CD138+) with long, slender, Auer-like inclusions (see figure) in 50% of the cells. Approximately 14% of the plasma cells had multinuclear forms.
Auer-like inclusions raise the possibility of acute nonlymphocytic leukemia (ANNL). However, the patient has been followed since the previous year with no evidence of ANNL. Rare instances of Auer-like inclusions within plasma cells have been previously reported. The mechanism by which they occ