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A male patient with a CBC reporting platelets 57×109/ L had no bleeding symptoms. The peripheral blood smear showed platelets in a ring around neutrophils. Pseudothrombocytopenia due to platelet satellitism shown by these images. platelet satellitism is an immunological phenomenon caused by the presence of natural antibodies, which form a bridge between platelets and neutrophils. The frequency of platelet satellitism is much lower than that of EDTA-dependent platelet clumping [1], but the real incidence of the phenomenon may be underestimated. Indeed, platelets counting involved in this cases is not so much lower than EDTA-dependent pseudothrombocytopenia. In these cases, the platelet satellitism should not only be found by morphology, but also the characteristic cell distribution in the scattergrams provided by the analyzers. [1]. Bizzaro, N. (1991). Platelet satellitosis to polymorphonuclears: Cytochemical, immunological, and ultrastructural characterization of eight cases. Am J Hematol, 36, 235–242.
Pseudothrombocytopenia due to platelet satellitism
#00018538
Author: Jianfeng Zhu
Category: Platelet and Megakaryocyte Disorders > Thrombocytopenia > Increased destruction or consumption of platelets > Idiopathic Thrombocytopenic Purpura
Published Date: 05/08/2013
Category: Platelet and Megakaryocyte Disorders > Thrombocytopenia > Increased destruction or consumption of platelets > Idiopathic Thrombocytopenic Purpura
Published Date: 05/08/2013
A male patient with a CBC reporting platelets 57×109/ L had no bleeding symptoms. The peripheral blood smear showed platelets in a ring around neutrophils. Pseudothrombocytopenia due to platelet satellitism shown by these images. platelet satellitism is an immunological phenomenon caused by the presence of natural antibodies, which form a bridge between platelets and neutrophils. The frequency of platelet satellitism is much lower than that of EDTA-dependent platelet clumping [1], but the real incidence of the phenomenon may be underestimated. Indeed, platelets counting involved in this cases is not so much lower than EDTA-dependent pseudothrombocytopenia. In these cases, the platelet satellitism should not only be found by morphology, but also the characteristic cell distribution in the scattergrams provided by the analyzers. [1]. Bizzaro, N. (1991). Platelet satellitosis to polymorphonuclears: Cytochemical, immunological, and ultrastructural characterization of eight cases. Am J Hematol, 36, 235–242.
