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Chest wall biopsy reveals monomorphic appearance of large cells and frequent mitoses indicating a rapidly growing tumor. The lymphoma cells express T-cell antigen CD45RO, ALK oncoprotein and CD30, and are negative for B cell antigen CD20, kappa and lambda light chains. Without immunohistochemical studies, this monomorphic appearance would be difficult to distinguish from a large cell lymphoma of B-cell origin. Importantly, the ALK+ lymphomas have a generally better prognosis than large B-cell lymphomas of similar stage.
Anaplastic Large Cell Lymphoma - 1.
#00003014
Author: Mark Lones
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 10/31/2011
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 10/31/2011
Chest wall biopsy reveals monomorphic appearance of large cells and frequent mitoses indicating a rapidly growing tumor. The lymphoma cells express T-cell antigen CD45RO, ALK oncoprotein and CD30, and are negative for B cell antigen CD20, kappa and lambda light chains. Without immunohistochemical studies, this monomorphic appearance would be difficult to distinguish from a large cell lymphoma of B-cell origin. Importantly, the ALK+ lymphomas have a generally better prognosis than large B-cell lymphomas of similar stage.
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