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This image best illustrates the difference between Pappenheimer bodies and Howell-Jolly bodies. The large arrow depicts a RBC with a Howell-Jolly body. Note: this is a single round dense structure with a regular border as opposed to the Pappenheimer bodies (small arrow) which are frequently multiple inclusions with irregular borders. Howell-Jolly bodies are fragments of DNA and typically seen in the peripheral smears of individuals with sickle cell disease following auto-splenectomy. A nucleated RBC is also present in this view. Pappenheimer bodies are abnormal granules of iron found inside red blood cells on a routine blood stain.