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Flow cytometric demonstration of the absence of CD59 on erythroid cells has become the standard by which PNH is diagnosed. This is a single parameter histogram which demonstrates 3 populations of erythrocytes in a patient with PNH. Type I cells are normal residual erythroyctes. Type III cells are PNH cells with complete deficiency of CD59 while Type II cells are PNH cells with partial deficiency.
Paroxysmal nocturnal hemoglobinuria - 1.
#00003858
Author: Peter Maslak
Category: Bone marrow failure > Acquired Bone marrow failure > Paroxysmal Nocturnal Hemoglobinuria
Published Date: 09/28/2011
Category: Bone marrow failure > Acquired Bone marrow failure > Paroxysmal Nocturnal Hemoglobinuria
Published Date: 09/28/2011
Flow cytometric demonstration of the absence of CD59 on erythroid cells has become the standard by which PNH is diagnosed. This is a single parameter histogram which demonstrates 3 populations of erythrocytes in a patient with PNH. Type I cells are normal residual erythroyctes. Type III cells are PNH cells with complete deficiency of CD59 while Type II cells are PNH cells with partial deficiency.
