Red cell agglutination

Red cell agglutination
Author: Teresa Scordino
Category: Morphologic variants of normal cells > Morphologic variants of Red Blood Cells/precursors > Normal Red blood cell morphology with resting lymphocyte for comparison > Other > Cold agglutinin
Published Date: 01/13/2016

•Clumping (agglutination) of red blood cells is frequently caused by cold agglutinins.  Cold agglutinins are IgM antibodies that may arise following viral or Mycoplasma infections, or in the setting of plasma cell or lymphoid neoplasms.  Agglutination of red cells can interfere with red blood cell indices.  The red blood cell count may be falsely decreased, and the MCV falsely increased, as clumps of red cells are measured as single cells.  The hemoglobin level will be accurate, as this parameter is measured after lysing the red cells.