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ALK-positive anaplastic large cell lymphoma BM involvement

ALK-positive anaplastic large cell lymphoma  BM involvement
#00060874
Author: Kristian T. Schafernak, M.D.
Category: Lymphoma: Mature T and NK cell lymphoproliferations > Mature T-cell Lymphomas > Anaplastic Large Cell Lymphoma, ALK positive
Published Date: 09/27/2016

Although immunohistochemistry for ALK and CD30 can be essential for detecting morphologically occult bone marrow involvement in ALK-positive anaplastic large cell lymphoma, this case from a child shows extensive involvement, with sheets of blasts occupying most of the marrow space in this field.  Note small populations of admixed eosinophils and erythroid precursors, and residual hematopoiesis seen at left and along the bottom of the image (hematoxylin and eosin).