Lymph node with Dermatopathic Lymphadenitis

Lymph node with Dermatopathic Lymphadenitis
Author: Sadhika Sood; Girish Venkataraman
Category: Lymph Node and Spleen: Reactive/infectious > Reactive nodal processes > Dermatopathic lymphadenitis
Published Date: 11/22/2017

Dermatopathic lymphadenitis (DL), also known as lipomelanosis reticularis or Pautrier-Woringer disease, showing expansion of the interfollicular region of the lymph node. It is a rare, benign, lymphatic hyperplasia, associated with a history of chronic dermatopathy-like eczema, pemphigus, psoriasis, mycosis fungoides, or toxic shock syndrome. The lymph node biopsy image shows melanin laden macrophages and histiocytes in the paracortical region. Lipid laden macrophages, Langerhans cells, eosinophils, interdigitating dendritic cells and plasma cells may also be seen in certain cases, however are not appreciated in this image. DL is a pitfall in lymphoma evaluation and hence should be considered in the differential diagnosis of lymphomas, especially in patients with prior occurrence of erythrodermal diseases.