CNS Peripheral T-Cell Lymphoma

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CNS Peripheral T-Cell Lymphoma

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Author: Liesl Butler, MBBS; Neil Came, MBBS, FRACP, FRCPA
Category: Laboratory Hematology > Body fluids: abnormal cells and microorganisms with cross-references to specific diagnoses when appropriate > Lymphoma cells in cerebral spinal fluid
Published Date: 01/15/2018

Image and flow cytometry plots refer to a cerebrospinal fluid (CSF) sample from a 56-year-old female with relapsed, refractory CD30-negative peripheral T-cell lymphoma manifest with symptomatic dural and leptomeningeal involvement on a background of previous lymph node, bone marrow, spleen and small bowel infiltration.

Cytology (figure 1) demonstrated a significant lymphocytosis comprising atypical small to medium-sized cells with profound nuclear membrane irregularities.

Flow cytometry (figure 2) showed that lymphocytes accounted for virtually all leukocytes and 64% were abnormal T-cells (colored black). Light scatter characteristics reflected their variable size. The lymphoma cells were CD2+ (not shown), CD3+, CD4- (not shown), CD5-, CD7+ (bright), CD8+ (not shown) and CD16/56+.

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