CLL - Smudge cells

CLL - Smudge cells
Author: Timothy C Carll, MD; Girish Venkataraman, MD, MBBS
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Low-grade B-cell lymphoma > Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Published Date: 03/23/2018

Smudge/basket cells in CLL


Due to the fragile nature of the CLL cells, they frequently get smudged during smear preparation. Hence, incubation with bovine serum albumin prior to smear preparation allows better preservation of CLL cells.