FISH showing Trisomy 12 in chronic lymphocytic leukemia (CLL)

Main Navigation
Account Navigation
Main Content

JavaScript is disabled on your browser

Please enable JavaScript or upgrade to a JavaScript-capable browser to use the ASH Image Bank.

COLLECTION

Images of peripheral blood and/or bone marrow of blood disorders and normal hematopoiesis.
ATLAS

Normal and abnormal blood cells
REFERENCE CASES

Complete cases of common blood disorders (peripheral blood, bone marrow, and diagnostic studies).
UPLOAD IMAGES

FISH showing Trisomy 12 in chronic lymphocytic leukemia (CLL)

#00061454

Author: Mr Anil Kumar Yadav, Dr Manorama Bhargava, India
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Low-grade B-cell lymphoma > Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Published Date: 05/29/2018

A 67-year-old man with chronic lymphocytic leukemia (CLL) having 61% lymphocyte on peripheral blood (PB). Fluorescence in situ hybridization (FISH) detected trisomy 12 in 15% of the cells analysed [30/200]. Trisomy 12 is found in 15-20%[cytogenetics-karyotyping] or 16-25 %[FISH] of CLL cases [http://atlasgeneticsoncology.org/Anomalies/CLLID2034.html]. FISH analysis for TP53 gene deletion (DC-Dual colour) and IgH breakapart (DC, BA) shows negative for deletion and gene rearrangement respectively in all the cells analysed (100%).

FISH with the CEN 12 Probe (Zytovision) on a peripheral blood cell sample, showing three interphase nuclei with two orange signal (in two cells- top and bottom nucei) and three orange signals (nuclei with trisomy 12- in centre).

Download Image