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Bone Marrow Fibrosis

Bone Marrow Fibrosis
#00061510
Author: Vincent Cracolici, MD; Girish Venkataraman, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Primary Myelofibrosis (PMF)
Published Date: 06/28/2018

Photomicrograph of a peripheral blood smear demonstrating multiple tear-drop shaped erythrocytes (“dacrocytes”). The associated bone marrow biopsy demonstrates numerous atypical, clustered megakaryocytes with cloud-like nuclei and cellular streaming suggestive of fibrosis. Upon further investigation, this patient was diagnosed with fibrotic stage of primary myelofibrosis.