CLL cells with cytoplasmic vacuoles

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CLL cells with cytoplasmic vacuoles

#00061676

Author: Mir Alikhan, MD
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Low-grade B-cell lymphoma > Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Published Date: 07/13/2018

Circulating atypical lymphoid cells with immunophenotype of chronic lymphocytic leukemia. The neoplasmic cells interestingly show cytoplasmic vacuolation. Studies have shown differential metabolic pathways in CLL cells compared with normal B-cells analogous to adipocytes and myocytes. There is also cytochemical and electron microscopic evidence that these vacuoles store lipids (Rozovski U, et al. Mol Cancer Res. 2015).

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