Moderate anisopoikilocytosis with Marked Reticulocytosis in a ß Thalassemia Intermedia child

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Moderate anisopoikilocytosis with Marked Reticulocytosis in a ß Thalassemia Intermedia child

#00062158

Author: Divya Rai, MD, MBBS; Manish Raturi, MD, MBBS
Category: Red Cell: Hemoglobin disorder
Published Date: 01/19/2019

1. A 3 year old male child complained of abdominal distension since 3 months and history of weight loss since 6 months.

2. On physical examination, he had pallor, frontal bossing and splenomegaly [8 cm below left subcostal margin].

3. His hemogram showed severe anaemia (Hb 2.9 g/dL), while peripheral smear showed moderate anisopoikilocytosis with marked reticulocytosis [4.8%]. Hemoglobin HPLC showed raised fetal Hb (HbF – 8.7%) and HbA2 (5.5 %) which is diagnostic of ß thalassemia intermedia .

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