#00062808

62 year old female with past history of ethnic leukopenia, who developed CML and became severely leukopenic while on treatment with imatinib.

Repeat marrow revealed infiltration with Pseudo-Gaucher cells. Pseudo-Gaucher cells are histiocytes with rounded, blue, lamellar cytoplasm resembling "onion skin" that can be found in up to 40% of the bone marrow of patients with CML. These are similar to glucocerebroside-stuffed histiocytes seen in Gaucher disease.