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Pseudo-Gaucher cells

Pseudo-Gaucher cells
#00062808
Author: Colette Spaccavento, MD; Morana Vojnic, MD, MBA
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Chronic Myelogenous Leukemia (CML), BCR-ABL1+ > Chronic phase
Published Date: 10/24/2019

62 year old female with past history of ethnic leukopenia, who developed CML and became severely leukopenic while on treatment with imatinib.

Repeat marrow revealed infiltration with Pseudo-Gaucher cells. Pseudo-Gaucher cells are histiocytes with rounded, blue, lamellar cytoplasm resembling "onion skin" that can be found in up to 40% of the bone marrow of patients with CML. These are similar to glucocerebroside-stuffed histiocytes seen in Gaucher disease.