Hemophagocytic activity in peripheral blood of a patient with autoimmune hemolytic anemia

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Hemophagocytic activity in peripheral blood of a patient with autoimmune hemolytic anemia

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Author: Shreyam Acharya; Aparna Ningombam; Abhirup Sarkar; Kundan Kumar
Category: Red Cell: Hemolytic Anemia (HA) > Autoimmune Hemolytic Anemias
Published Date: 01/13/2020

A 20-year-old female patient attended the emergency ward with a 5 days history of fever and severe weakness. A complete hemogram showed reduced hemoglobin of 68 gm/L with a severe reduction in RBC numbers (0.78 million/microlitre). RBC indices were found to have abnormally increased with a mean corpuscular volume of 130 femtolitres, mean corpuscular hemoglobin of 45 picograms and mean corpuscular hemoglobin concentration of 400 gm/L.

Peripheral smear examination revealed RBC agglutinates with very occasional hemophagocytic activity. The image shows a hemophagocytic cell with the presence of platelets and nucleus of a lymphocyte in the cytoplasm.

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