AML with inv(16)- Bone Marrow Aspirate

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AML with inv(16)- Bone Marrow Aspirate

#00063048

Author: Manisha Goel; Girish Venkataraman
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
Published Date: 06/24/2020

Aspirate smear shows blasts (Black arrows) with folded monocytoid nuclei and prominent nucleoli along with immature abnormal eosinophils (Red arrow). Note the presence of strikingly large basophilic granules in one of the abnormal eosinophil, a characteristic for this entity. These abnormal eosinophils may demonstrate faint Cholroacetate esterase positivity (negative in normal eosinophils).

This is one of the genetic abnormalities, which is considered as AML, even if blast count is <20% in bone marrow. In cases with suggestive cellular morphology, but negative conventional cytogenetics, additional FISH or RT-PCR is recommended to document this genetic alteration.

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