Acute Myeloid Leukemia with t(8;21)(q22;q22)

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Acute Myeloid Leukemia with t(8;21)(q22;q22)

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Author: Bernardo López Andrade, MD; Maria Antonia Duran Pastor, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
Published Date: 07/28/2020

A 40-year-old male with acute myeloid leukemia debut with typical t(8;21) morphology in the peripheral blood film. Presence of 31% of agranular and granular myeloblasts in peripheral blood, most of them present a clear pale cytoplasm with a basophilic ring on the cytoplasmic rim (A, B). The presence of large and sharp Auer rods is frequent (B). Isolated pseudo-chediak granules were observed in the Peroxidase staining. (C).

The bone marrow examination confirmed the diagnosis of AML and cytogenetics confirmed 46,XY,t(8;21)(q22;q22)[11]/46,XY[10].

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