Megakaryocytes and micromegakaryocytes in peripheral blood of a patient with acute myeloid leukemia

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Megakaryocytes and micromegakaryocytes in peripheral blood of a patient with acute myeloid leukemia

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Author: Miguel Augusto Pereira, MD; Suelen Brito Nascimento, MSc; Hye Chung Kang, MSc, PhD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia
Published Date: 10/08/2020

A 34-year-old female patient with dyspnea, fever, pale, with a pancardiac murmur and diffuse snores in the chest. Laboratory tests revealed anemia (5.1g / dL), leukocytosis (54.800mm3) with 94% of blasts. The peripheral blood smear had Auer rods, megakaryocytes and rare micromegakaryocytes. The condition was suggestive of acute myeloid leukemia.

(A) Peripheral blood smear in 10x magnification where it is already possible to observe some megakaryocytes. (B and C) Micromegakaryocytes surrounded by several blast cells. (D, E, F, G and H) Dysplastic megakaryocytes. (I) Empiripolisis of hematopoietic cells.

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