Megakaryoblastic Crisis in Bone Marrow

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Megakaryoblastic Crisis in Bone Marrow

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Author: Adam Hines, MD; Sunita Patruni, MD; Vernon Wu, MD; Carlos Lopez, MD; Judith Brody, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Chronic Myelogenous Leukemia (CML), BCR-ABL1+ > Blast phase
Published Date: 04/15/2021

Megakaryoblastic Blast Crisis in the setting of known Chronic Myelogenous Leukemia diagnosis with the bone marrow showing hypercellularity with increased CD34+ blasts (up to 8% of cellularity) and increased megakaryoblasts at least >5% with dim Factor VII and CD61 staining. The basophilic granular appearance with cytoplasmic pseudoblebs are characteristic of megakaryoblasts.

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