Lipid-laden Monocytes in Peripheral Blood of a Patient with Hemoglobin SC Disease in Crisis

Lipid-laden Monocytes in Peripheral Blood of a Patient with Hemoglobin SC Disease in Crisis
#00063882
Author: Mel Gravenstede, B.S.; Sandra Haddad, M.D.; Kristina Gvozdjan, M.D.
Category: Red Cell: Hemoglobin disorder > Sickle cell anemia and related sickling syndromes
Published Date: 12/09/2021

Lipid-laden monocytes (1a-1c) were noted in peripheral blood of a patient with hemoglobin SC disease in crisis who was diagnosed with bone marrow necrosis / fat embolism syndrome on postmortem examination.  A section of the patient’s lung with lipid droplets highlighted in black following tissue osmication is shown in 1d.