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We present the case of a patient who came to our attention for the onset of an itchy erythematous lesion spread over the whole soma (poorly responsive to cortisone therapy) and subjected to biopsy, diagnosed with mycosis fungoides. First-line therapy with bexarotene was initiated, with no response, so it was decided to treat the patient with subsequent lines of therapy (gemcitabine, photopheresis, brentuximab). For further disease progression, the patient underwent therapy with mogamulizumab (humanized and defucosylated immunoglobulin IgG1 kappa, which binds the CCR4). After 5 administrations of this therapy, there was a further worsening of the clinical picture, with desquamating skin lesions alternating with areas of necrosis, itchy and sporadically ulcerated (figure 1 A-B-C-D), leading the patient to a progressive deterioration of the clinical conditions up to death from multiple organ failure. Despite the existence of numerous drugs effective against cutaneous T lymphomas (TCL), these remain pathologies of important impact for the patient's health, leading, above all, to a serious and dramatic deterioration in the quality of life.