AML with t(8;21) and NRAS mutation

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AML with t(8;21) and NRAS mutation

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Author: Ke Xu, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
Published Date: 03/22/2022

A 79-year-old female presented with WCC 390 x10^9/L. Bone marrow smear was effaced with large blasts with prominent nucleoli and occasional Auer rods. FISH identified t(8;21). Myeloid NGS showed NRAS mutation. She was treated with leukopheresis, hydroxycarbamide, followed by venetoclax and azacytidine to complete morphological remission.

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