Pure Erythroid Leukemia

Pure Erythroid Leukemia
Author: Asish Rath; Deepak Kumar Goel; Sushant S. Vinarkar; Mayur Parihar; Deepak Kumar Mishra
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > AML not otherwise specified > Acute erythroid leukemia
Published Date: 06/06/2022

Peripheral blood smear (panel A) shows circulating blasts with nucleated RBCs.  Bone marrow aspirate (panel B-C) shows marked erythroid hyperplasia with predominance of proerythroblasts. Myeloperoxidase (MPO) cytochemial stain (panel D) is positive in scattered myeloblasts. Periodic acid-schiff (PAS) staining (panel E) shows diffuse granular positive in anormal erythroid cells. Bone marrow biopsy (panel F) shows erythroid hyperplasia and predominance of proerythroblasts. CD71 immunohistochemistry (panel G) highlights marked erythroid hyperplasia. CD41 immunostain (panel H) dysmegakaryopoiesis along with micromegakaryocytes.