Copper and vacuolations

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Copper and vacuolations

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Author: Abhishek Dashora, MD,FRCPath; Kathryn Foucar, MD
Category: Red Cell: Disorders of Iron Metabolism and Heme Synthesis > Sideroblastic anemias > Acquired/Reversible Sideroblastic Anemias > Copper deficiency
Published Date: 06/07/2022

The patient is a 2 year old male with microvillus inclusion disease on total parenteral nutrition. He experienced new onset pancytopenia. WBC 2.5 (ANC 0.5), H/H 9.6/27, and plt 62.

Bone marrow aspirate showing prominent cytoplasmic vacuolation in erythroid precursors.

This finding could also be seen in myelodysplastic syndrome, Pearson syndrome and acute alcoholic intoxication; hence a clinico-pathological correlation is essential.

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