Blasts in APL hypogranular

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Blasts in APL hypogranular

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Author: Najmaldin Saki Ph.D; Bita Bandar M.Sc; Zeinab Eftekhar M.Sc
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 04/24/2023

The peripheral blood smear showing different types of myelobast in patient diagnosed with Acute Promyelocytic Leukemia(APL) variant (FAB: M3v). Microgranular/Hypogranular APL blasts have distinct morphologic features such as irregular bilobed nucleus and paucity or absence of granules compared to typical APL(hypergranular). Note that these cells might be confused with monoblasts.

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