Pseudo-Gaucher cell in Chronic Myeloid Leukemia

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Pseudo-Gaucher cell in Chronic Myeloid Leukemia

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Author: Martin Pacheco, MD; Juan Manuel Pérez-Zúñiga, MD; Eleazar Hernández-Ruiz, MD; Leire Montoya-Jiménez, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Chronic Myelogenous Leukemia (CML), BCR-ABL1+
Published Date: 05/19/2023

52 year old male with hyperleukocytosis, splenomegaly and weight loss is evaluated for suspected MPN. Bone marrow aspirate shows hypercellular marrow with absolute myeloid hyperplasia and myelocyte bulge. Scant histiocytes with cytoplasm containing needle-like inclusions were observed (pseudo-Gaucher cells). An RT-PCR revealed the presence of t(9;22)(q34;q11) BCR-ABL1 (M-bcr, p210).

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