Pseudo-Gaucher cell in Chronic Myeloid Leukemia

Pseudo-Gaucher cell in Chronic Myeloid Leukemia
Author: Martin Pacheco, MD; Juan Manuel Pérez-Zúñiga, MD; Eleazar Hernández-Ruiz, MD; Leire Montoya-Jiménez, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Myeloproliferative Neoplasms (MPN) > Chronic Myelogenous Leukemia (CML), BCR-ABL1+
Published Date: 05/19/2023

52 year old male with hyperleukocytosis, splenomegaly and weight loss is evaluated for suspected myeloproliferative neoplasm. Bone marrow aspirate shows myeloid hyperplasia with myelocyte bulge. A histiocyte with cytoplasm containing needle-like inclusions is observed (pseudo-Gaucher cell). RT-PCR revealed the presence of t(9;22)(q34;q11) BCR::ABL1 (M-bcr, p210).