Delayed Haemolytic Transfusion Reaction

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Delayed Haemolytic Transfusion Reaction

#00064602

Author: Mustapha Dibbasey; Francess Sarfo; Rosyna Begum; Mamudou Dahaba
Category: Red Cell: Hemolytic Anemia (HA)
Published Date: 10/12/2023

A 51-year-old woman with a recent history of RhD incompatible blood transfusion presented to the clinic with jaundice, severe anaemia (HB=3.6g/dL), thrombocytopenia (PLT=2x10³/uL) and leucocytosis (WBC=20.80x10³/uL) but normal PT (12.80secs) and PTT (33.8 secs). The liver function test showed elevated total bilirubin of 28.50umol/L. The peripheral blood film showed features of extravascular haemolysis characterised by marked polychromatic cells, spherocytes, nucleated red blood cells and RBCs aggregates/clumps. Extravascular haemolysis that occurs within the confines of the reticuloendothelial system is a typical hallmark of delayed haemolytic transfusion reaction. The direct antiglobulin test was positive as well.

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