Hairy Cell Leukemia

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Hairy Cell Leukemia

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Author: Davood Bashash; Amir-Mohammad yousefi; Bahareh Bashiri; Zahra Ghorbani
Category: Lymphoma: Mature B-cell and Plasma cell Neoplasms > Splenic lymphomas > Hairy Cell Leukemia
Published Date: 08/21/2023

Hairy cell leukemia (HCL) is an uncommon indolent lymphoid malignancy characterized by the accumulation of neoplastic B cells with abundant cytoplasm and "hairy" projections within the peripheral blood, bone marrow, and spleen. HCL is postulated to arise from a late, activated memory B cell exhibiting pre-plasma cell or post-germinal center features and it is associated with pancytopenia and infectious complications due to progressive infiltration of the bone marrow and spleen.

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