APL microgranular

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APL microgranular

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Author: Kaveh Jaseb MD; Najmaldin Saki Ph.D; Bita Bandar M.Sc; Fatemeh Bakhshipour M.Sc; Narjes Sadat Sadati M.Sc
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with t(15;17)(q22;q12); PML-RARA (and variants)
Published Date: 11/30/2023

This image shows the peripheral blood smear of a 16 year-old male patient diagnosed with Acute Promyelocytic Leukemia(APL) variant or microgranular (FAB:M3v). The patient has respiratory distress (SatO2 90%) complicated with DIC (D-dimer >2000 ng/mL) subsequent to All-Trans Retinoic Acid (ATRA) treatment. Laboratory analysis revealed leukocytosis (WBC= 135,700 /μL), hemoglobin of 9 g/dL and platelet of 156 ×10^3 cells/μL. The APL variant morpholoy is representative of neoplastic promyelocytes with sparse fine azurophilic granules and infrequent Auer rods, or no granules. In addition, Myeloblasts with bi-lobed or multi-lobed nucleus are present.

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