#00064897

The image shows different types of lymphoid cells in the peripheral blood smear of a 69 year-old male patient diagnosed with Splenic B-cell Lymphoma/Leukaemia with Prominent Nucleoli (SBLPN) or previously called Hairy Cell Leukemia type variant (HCL-v).(blood WBC count:39.60 ×10^9/L)
The neoplastic lymphoid cells are hybrids, with an intermediate morphology between prolymphocytes and hairy cells. Neoplastic lymphoid cells are medium-sized with prominent nucleolus and hair-like cytoplasmic projections which may resemble the hairy cells. SBLPN is rare and the neoplastic cells are negative for HCL markers CD25, annexin A1, TRAP, and CD123.