Acute myeloid leukemia with Cup-like blasts 3

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Acute myeloid leukemia with Cup-like blasts 3

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Author: Diego Garzón, MD; Elizabeth Rentería Castillo, MD
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with mutated NPM1
Published Date: 01/10/2024

A 66 year-old man presented significant weight loss, bone pain, fever and anemic syndrome. His blood count showed hyperleukocytosis with 340,000 per μL, hemoglobin of 6.6 g/dL and platelet count of 33,000 per μL.

Peripheral blood smear with Wrigth-Giemsa revealed 90% blasts with a cup-shaped nuclear morphology which is significantly associated with mutations in FLT3 and NPM1 genes.

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